We are always looking for talented individuals to work with us!

Einstein Postdocs: einstein@choderalab.org
Postdocs: postdoc@choderalab.org
Technicians: apply@choderalab.org
Prospective graduate students: You can join the lab from any of these graduate programs:

OPEN POSITIONS

CHODERA LAB SEEKING AWESOME TECH TO HELP ADVANCE DRUG DISCOVERY SCIENCE WITH ROBOTS!

Research Tech Salary: $22.06-$33.18 hourly

What we’re looking for:

  • Life, physical sciences, or engineering BS/BA degree

  • Familiarity with Python and linux

  • Strong organizational skills (including within a wet lab setting; maintaining a lab notebook, inventory management/upkeep, etc.)

  • Interested in working with the Chodera Lab for at least two years

  • Most importantly, an unbounded enthusiasm for SCIENCE!

Other bonus (but not required!) experience:

  • Eagerness to learn about (or have previous experience with) laboratory robotics and automation

  • Basic knowledge of biochemistry and/or molecular biology

  • Interest in enzymatic assays

  • Knowledge of regression/curve fitting methods

  • Experience with bacterial protein expression, purification, and related molecular biology skills

  • Experience with electronic and hard-copy lab notebooks

What we're offering:

  • Highly competitive pay for research technicians ($22.06-$33.18 hourly; Yearly can range $41,900 – $62,900)

  • Flexible hours/freedom to work part-time at home

  • Working at the interface of automated experiments, machine learning, open-source software, and drug discovery within the Memorial Sloan Kettering Cancer Center / Tri-Institutional research campus in Manhattan

  • Networking opportunities with many of the pharma and biotech collaborators we work with

  • Training to help you move to the next phase of your career. Technicians in the lab have gone on to graduate programs (George Washington University), medical school (NYU Medical School), pharma (BioNTech), and biotech startups (Kingdom Supercultures).

Projects in the lab you'll be involved with:

  • Measure the impact of clinically identified mutations on clinical kinase-inhibitor binding, particularly focusing on identifying resistant mutations

  • Conduct high throughput assays measuring the impact of clinical kinase mutations on kinase activity

  • Collect systematic biophysical data on kinase-inhibitor binding in the context of clinical mutations to aid in the development of computational models and machine-learning tools

  • Lead a project collecting biophysical data to support the development of computational tools for predicting when cancer patients will respond to clinical kinase inhibitors

    • Design and execute machine learning and physics-based modeling projects to predict the impact of kinase mutations on inhibitor binding

  • Assess the accuracy of various probabilistic programming models compared to experimental data, train new models, identify datasets to collect, and design experiments to improve models

  • Drive new experimental approaches that include cell-free protein expression protocols and/or paper-based microfluidics to reduce the overall experiment time and cost

  • Assist in small infrastructure programming/maintenance projects (e.g. automation system dashboard)

Your main responsibilities in the lab would include:

  • Perform Lab Experiments (~50%): Assist ongoing research by conducting biophysical experiments for lab personnel and collaborators

  • Conduct Data Analysis/Reporting (~40%): Perform necessary analysis and calculations, record data, and write reports on research findings

  • Inventory Control/Quality Assurance (~5%): Help with the general upkeep of the wet lab

  • Additional Administrative Support (~5%): When our primary administrator is unable to assist

Location:

We’re looking to hire someone within the NYC area who will be able to easily commute into **Mortimer B. Zuckerman Research Center daily.**

How to apply:

Send an email to apply@choderalab.org with the following information:

  • Your contact information

  • A short note on why you’re interested

  • A current CV or resumé

  • An indication of the rough compensation range you’re looking for; we’re flexible here and will try to make things work if it looks like a good fit

You can also apply via the MSKCC Career portal but please reference the Chodera Lab in your application and cover letter.

We’ll start contacting promising applicants immediately, but official offers will be made pending final approval of funding from MSKCC.

Seeking software scientists to come work with Folding@home, OpenMM, and open source software for drug discovery

Want to come help us build awesome open source software for drug discovery, work with the world’s biggest distributed computing platform (Folding@home), and make GPU-accelerated free energy calculations and molecular simulations within the OpenMM ecosystem even more powerful? Enjoy working with cross-disciplinary teams of developers, and scientists to make software that powers awesome discoveries? We’re looking for software scientists to join us!

What we’re looking for:

  • Someone with an aptitude for Python, and potentially also C++/CUDA/OpenCL

  • You speak Python at a level where you are comfortable writing classes with inheritance, your own decorators and context managers, and parameterized unit tests.

  • Your IDE is configured with modern tooling like black autoformatting, pylint, and AI-assisted autocompletion

  • We make extensive use of git and GitHub: branches, forks, PRs, rebasing, cherry-picking are not foreign concepts to you

  • Your exploratory work happens in notebooks and you like when they look pretty

  • Code reviews do not sound scary but exciting

  •  You have a passion for working together with other software developers, software scientists, and scientists to make awesome, usable tools for science; we work closely with organizations like the Molecular Sciences Software Institute (MolSSI) to jointly develop software best practices (see our own best practices and MolSSI’s ) to better enable the community to collaborate and to ensure our students and postdocs are familiar with best practices used in industry

  • You are excited to collaborate with other organizations like Folding@home, the Open Force Field Initiative, the Drug Design Data Resource (D3R), and the Molecular Sciences Software Institute (MolSSI)

  • You possess a good measure of patience in working with a variety of different kinds of people

  • You’re excited about contributing to some amazing scientific initiatives in open science, drug discovery, and open source software to enable this

  • You can ensure at least a few key hours of your workday overlap normal NYC working hours (M-F 10-5)

Other bonus (but certainly not required!) experience:

  • You have Python packaging experience with conda, which makes it easy to deploy tools and their dependencies (including GPU-accelerated tools). Huge bonus points if you’ve contributed to the fantastic packaging ecosystem conda forge

  • You have enough CI experience to be excited by GitHub Actions. Green check marks make you happy.

  • You have any experience with biomolecular simulation theory and/or simulation packages (especially OpenMM) is a huge plus

  • You have any exposure to the concepts or tools of Markov chain Monte Carlo, since a lot of our algorithms are based on these concepts

  • You have a degree (BS, PhD) in the physical  or biosciences or computer-focused discipline, but this is certainly not required

  • You have some experience with cloud dev ops (e.g. AWS EC2, S3, AWS Batch) is a plus, since we’re starting to migrate some Folding@home workflows there

Location:

We’re open to people living anywhere! We’re looking to contract out remotely for the time being, with the option to hire you in-person in NYC (either initially or in the future). 

How to apply:

Send an email to apply@choderalab.org with the following information:

  • Your contact information

  • A short note on why you’re interested A current CV or resumé

  • Links to a GitHub page (if you have one!) or any other

  • An indication of the rough compensation range you’re looking for; we’re flexible here, and will try to make things work if it looks like a good fit

We’ll start contacting promising applicants right away, but official offers will be made pending final approval of funding from MSKCC.