An alternative explanation for the catalytic proficiency of orotidine 5'-phosphate decarboxylase

Tai-Sung Lee*, Lillian T. Chong*, John D. Chodera, and Peter A. Kollman. 
* These authors contributed equally to the work. 
J. Am. Chem. Soc., 123 (51):12837-12848 (2001) [DOI] [PDF]

A combined QM and MD analysis of potential plausible mechanisms to explain the enormous catalytic acceleration of one of the most proficient enzymes known.